Slide background
Slide background




IARC Monographs Volume 130

ID 17547 | | Visite: 1726 | Documenti ChemicalsPermalink: https://www.certifico.com/id/17547

IARC Monographs Volume 130

IARC Monographs Volume 130

This volume of the IARC Monographs provides evaluations of the carcinogenicity of five industrial chemicals: 1,1,1-trichloroethane, 1,2-diphenylhydrazine, diphenylamine, N-methyloIacrylamide, and isophorone.

1,1,1-Trichloroethane was used extensively until the 1990s as a solvent, metal degreaser, chemical intermediate. Since the Montreal Protocol on Substances that Deplete the Ozone Layer, production and use have dwindled, and it is now mostly used as a chemical feedstock in closed systems and for “essential uses”. Poorly documented non-essential uses might occur in low-income and middle-income countries.

1,2-Diphenylhydrazine was primarily used as an intermediate in the manufacture of benzidine dyes, which has ceased in the USA and European Union, although production might occur elsewhere. Additional uses include as an intermediate in drug manufacture.

Diphenylamine, N-methylolacrylamide, and isophorone are High Production Volume chemicals and intermediates used for a wide range of industrial applications. The use of diphenylamine in agrochemicals to prevent fruit scalding is prohibited in the European Union, but ongoing in the USA and elsewhere. Isophorone has been detected in numerous polymer-based products from food packaging to aquatic inflatables, and in food items, possibly because of agrochemical contamination or migration from packaging.

For all agents, data were sparse regarding exposure levels (apart from 1,1,1-trichloroethane, for which data were available mainly on exposures pre-dating the adoption of the Montreal Protocol), but indicated that exposures are higher in occupational situations than in the general population.

An IARC Monographs Working Group reviewed evidence from cancer studies in humans (available for 1,1,1-trichloroethane), cancer bioassays in experimental animals, and mechanistic studies to assess the carcinogenic hazard to humans of exposure to these agents and concluded that:

- 1,1,1-Trichloroethane is probably carcinogenic to humans (Group 2A)
- 1,2-Diphenylhydrazine, diphenylamine, N-methyloIacrylamide, and isophorone are possibly carcinogenic to humans (Group 2B).

...

Fonte: IARC

Collegati

Descrizione Livello Dimensione Downloads
Allegato riservato IARC Monographs Volume 130.pdf
 
10102 kB 6

Tags: Chemicals Abbonati Chemicals Agente chimico

Articoli correlati

Ultimi archiviati Chemicals

ECHA compendium of analytical methods
Giu 27, 2025 260

ECHA compendium of analytical methods for enforcing REACH restrictions - Ed. 3.0 2025

ECHA compendium of analytical methods for enforcing REACH restrictions - Ed. 3.0 2025 ID 24178 | 27.06.2025 / Attached ECHA has updated its compendium of analytical methods to help authorities to enforce and companies to comply with REACH restrictions. The compendium consists of a collection of… Leggi tutto
ECHA 2025   Key Areas of Regulatory Challenge
Giu 11, 2025 849

ECHA 2025 - Key Areas of Regulatory Challenge

ECHA 2025 - Key Areas of Regulatory Challenge ID 24098 | 11.06.2025 / Attached The report introduces new topics to reflect ECHA’s growing responsibilities. It also covers emerging topics in waste and recycling that aim to support circularity and enhance Europe’s industrial competitiveness. For… Leggi tutto
REACH Authorisation List
Giu 09, 2025 850

REACH Authorisation Decisions List / Last update: 23.05.2025

REACH Authorisation Decisions List / Last update: 23.05.2025 ID 24091 | Last update: 09.06.2025 REACH Authorisation Decisions List of authorisation decisions adopted on the basis of Article 64 of Regulation (EC) No 1907/2006 (REACH). The list also includes reference to related documentation… Leggi tutto
In situ generated active substances and their products
Giu 07, 2025 916

In situ generated active substances and their products

In situ generated active substances and their products / ECHA Aprile 2025 ID 24087 | 07.06.2025 / Version 2 April 2025 Information requirements and risk assessment for approval and authorisation Recommendations of the BPC Working Groups.________ Il presente documento ha lo scopo di assistere gli… Leggi tutto
Giu 06, 2025 1058

Rettifica regolamento (UE) 2023/2055 - 06.06.2025

Rettifica regolamento (UE) 2023/2055 - 06.06.2025 ID 24080 | 06.06.2025 Rettifica del regolamento (UE) 2023/2055 della Commissione, del 25 settembre 2023, recante modifica dell’allegato XVII del regolamento (CE) n. 1907/2006 del Parlamento europeo e del Consiglio concernente la registrazione, la… Leggi tutto
Documento di orientamento CE condizioni d uso simili in tutta l Unione biocidi
Giu 04, 2025 965

Documento di orientamento CE condizioni d'uso simili in tutta l’Unione biocidi

Documento di orientamento CE condizioni d'uso simili in tutta l’Unione biocidi ID 24073 | 04.06.2025 / In allegato Comunicazione della Commissione - Documento di orientamento sulla definizione di condizioni d'uso simili in tutta l'Unione conformemente all'articolo 42, paragrafo 2, del regolamento… Leggi tutto

Più letti Chemicals

Notifica HACCP
Apr 05, 2022 102925

Notifica ai fini registrazione Regolamento CE n. 852/2004

Notifica ai fini della registrazione (Reg. CE n. 852/2004) - Ex notifica sanitaria alimentare ID 7901 | 06.03.2019 / Modello notifica allegato [panel]Regolamento (CE) 852/2004...Articolo 6 Controlli ufficiali, registrazione e riconoscimento 1. Gli operatori del settore alimentare collaborano con le… Leggi tutto