Slide background
Slide background




Chromium VI compounds - Recommendation SCOEL

ID 4546 | | Visite: 3668 | Documenti Chemicals UEPermalink: https://www.certifico.com/id/4546

Chromium VI compounds
Recommendation from the Scientific Committee on Occupational Exposure Limits

The critical effect of the occupational inhalation of hexavalent chromium (CrVI) -containing compounds is lung cancer. In addition, occupational exposure can lead to nephrotoxicity, hypersensitivity (sensitization), corrosion of the skin, irritation of the respiratory tract and gastrointestinal tract. Cr VI compounds have been classified as a carcinogen, in Category 1 based on both humans and animal data by IARC.

Most Cr VI compounds are classified by the European Union in Category 1B (substance presumed to be carcinogenic to humans).

The exceptions are chromium trioxide, zinc chromate and zinc potassium chromate which are classified in Category 1A (substance known to be carcinogenic to humans). Reevaluation of the information on the mode of action underlying carcinogenicity has resulted in the conclusion that in case of CrVI the formation of ternary DNA adducts are relevant. These DNA lesions are not easily repaired and eventually may lead to the outgrowth of repair-deficient cell clones exerting genomic instability. Thus, Cr VI acts as a directly genotoxic carcinogen for which no threshold can be assumed and for which, linear extrapolation is commonly applied by SCOEL in this situation if the available data permits.
...

Contents

1. CHEMICAL AGENT IDENTIFICATION AND PHYSICO-CHEMICAL PROPERTIES
2. EU HARMONISED CLASSIFICATION AND LABELLING
3. CHEMICAL AGENT AND SCOPE OF LEGISLATION
4. EXISTING OCCUPATIONAL EXPOSURE LIMITS
5. OCCURRENCE, USE AND OCCUPATIONAL EXPOSURE
5.1. Occurrence
5.2. Production and use information
5.3. Occupational exposure
5.4. Routes of exposure and uptake
6. MONITORING EXPOSURE
6.1. External exposure
6.2. Internal exposure/Biomonitoring of exposure
7. HEALTH EFFECTS
7.1. Toxicokinetics (absorption, distribution, metabolism, excretion)
7.1.1. Human and animal data
7.1.2. Animal data
7.1.3. In vitro data
7.1.4. Toxicokinetic modelling
7.1.5. Biological monitoring
7.2. Acute toxicity
7.2.1. Human data
7.2.2. Animal data
7.3. Specific Target Organ Toxicity/Repeated Exposure
7.3.1. Human data
7.3.2. Animal data
7.4. Irritancy and corrosivity
7.4.1. Human data
7.4.2. Animal data
7.5. Sensitisation
7.5.1. Human data
7.6. Genotoxicity
7.6.1. Human data
7.6.2. Animal data
7.6.3. In vitro
7.7. Carcinogenicity
7.7.1. Human data
7.8. Reproductive toxicity
7.8.1. Human data
7.8.2. Animal data
7.9. Mode of action and adverse outcome pathway considerations
7.10. Lack of specific scientific information
8. CANCER RISK ASSESSMENT
9. GROUPS AT EXTRA RISK
10. REFERENCES

Fonte: Commissione Europea 2017 - SCOEL/REC/386

Articoli correlati:

Triossido di Cromo: il 21 Settembre 2017 termina l'uso in UE

DescrizioneLinguaDimensioneDownloads
Scarica questo file (Chromium VI compounds.pdf)Chromium VI compounds.pdf
SCOEL/REC/386
EN1394 kB2498

Tags: Chemicals Reach Regolamento CLP

Articoli correlati

Ultimi archiviati Chemicals

Recast Drinking Water Directive
Lug 01, 2022 42

Recast Drinking Water Directive, state of play

Recast Drinking Water Directive, state of play EU JRC - June 2022 Guidance note for the analysis of microbiological parameters The quality of drinking water in the European Union is verified by measuring parameters established in the recast of the Drinking Water Directive (DWD) 2020/2184. Compared… Leggi tutto
Giu 24, 2022 56

Regolamento (UE) 2021/2142

Regolamento (UE) 2021/2142 Regolamento (UE) 2021/2142 della Commissione del 3 dicembre 2021 che modifica il regolamento (CE) n. 1881/2006 per quanto riguarda i tenori massimi di alcaloidi oppiacei in alcuni prodotti alimentari. (GU L 433 del 6.12.2021) Collegati[box-note]Regolamento (CE) n.… Leggi tutto
Faster action on groups of harmful chemicals
Giu 17, 2022 87

ECHA - Integrated Regulatory Strategy (IRS) Annual Report 2021

ECHA - Integrated Regulatory Strategy (IRS) Annual Report 2021 Faster action on groups of harmful chemicals - Integrated Regulatory Strategy Annual Report June 2022 Helsinki, 17 giugno 2022 È stato pubblicato il quarto rapporto dell'ECHA nell'ambito della sua strategia di regolamentazione… Leggi tutto
Mag 31, 2022 112

Decreto 11 ottobre 2001

Decreto 11 ottobre 2001 Condizioni per l'utilizzo dei trasformatori contenenti PCB in attesa della decontaminazione o dello smaltimento. (GU n.255 del 02.11.2001) Collegati
D.P.R. 24 maggio 1988, n. 216Decreto Legislativo 22 maggio 1999 n. 209
Leggi tutto
Mag 31, 2022 128

D.P.R. 24 maggio 1988, n. 216

D.P.R. 24 maggio 1988, n. 216 Attuazione della direttiva CEE n. 85/467 recante sesta modifica (PCB/PCT) della direttiva CEE n. 76/769 concernente il ravvicinamento delle disposizioni legislative, regolamentari ed amministrative degli Stati membri relative alle restrizioni in materia di immissione… Leggi tutto

Più letti Chemicals

Regolamento  CE  n  178 2002
Mar 17, 2022 65043

Regolamento (CE) N. 178/2002

Regolamento (CE) n. 178/2002 Regolamento (CE) n. 178/2002 del Parlamento europeo e del Consiglio del 28 gennaio 2002 che stabilisce i principi e i requisiti generali della legislazione alimentare, istituisce l'Autorità europea per la sicurezza alimentare e fissa procedure nel campo della sicurezza… Leggi tutto