Slide background
Slide background




IARC Monographs Volume 94

ID 16301 | | Visite: 2719 | Documenti Chemicals EntiPermalink: https://www.certifico.com/id/16301

IARC Monographs Volume 94

IARC Monographs Volume 94 / Ingested Nitrate and Nitrite, and Cyanobacterial Peptide Toxins - Ed. 2010

ID 16301 | 01.04.2022 / In allegato

This ninety-fourth volume of IARC Monographs contains evaluations of the carcinogenic hazard to humans of ingested nitrate and nitrite, microcystins and nodularin. This is the first Monographs review of these agents, which were nominated as high priorities for future evaluation by the most recent Advisory Group (IARC, 2003).

In view of the body’s conversion of nitrate to nitrite and then to N-nitroso compounds, interpretation of the epidemiological studies on nitrate/nitrite ingestion was aided by mechanistic information on factors that accelerate or inhibit this conversion.

Some epidemiological studies of high nitrate ingestion primarily from vegetables found reduced risks of gastric cancer, while other studies of nitrate/nitrite ingestion from nitritepreserved meats found increased risks.

Mechanistic studies show that the formation of Nnitroso compounds is accelerated by the presence of nitrosatable compounds (found in meat) and inhibited by vitamin C and other antioxidants (found often in vegetables).

These inferences about N-nitrosamine formation are consistent with the epidemiological studies that examined interactions between nitrite and antioxidants and with the animal bioassays that investigated various combinations of nitrate/nitrite, nitrosatable compounds, and antioxidants.

The cancer hazard from nitrate/nitrite ingestion cannot be determined without considering these other factors. Accordingly, the Working Group defined the agent not as “ingested nitrate or nitrite”, but as “ingested nitrate or nitrite under conditions that result in endogenous nitrosation”. This marks the first use of a mechanistic event (endogenous nitrosation) leading to carcinogenesis in the wording of an evaluation statement.
...

Classification: Group 2A

Ingested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A).

add more in attachment

Collegati

Descrizione Livello Dimensione Downloads
Allegato riservato IARC Monographs Volume 94.pdf
IARC 2010
4775 kB 3

Tags: Chemicals Abbonati Chemicals Agente chimico

Articoli correlati

Ultimi archiviati Chemicals

REACH Authorisation List
Giu 09, 2025 96

REACH Authorisation Decisions List / Last update: 23.05.2025

REACH Authorisation Decisions List / Last update: 23.05.2025 ID 24091 | Last update: 09.06.2025 REACH Authorisation Decisions List of authorisation decisions adopted on the basis of Article 64 of Regulation (EC) No 1907/2006 (REACH). The list also includes reference to related documentation… Leggi tutto
In situ generated active substances and their products
Giu 07, 2025 168

In situ generated active substances and their products

In situ generated active substances and their products / ECHA Aprile 2025 ID 24087 | 07.06.2025 / Version 2 April 2025 Information requirements and risk assessment for approval and authorisation Recommendations of the BPC Working Groups.________ Il presente documento ha lo scopo di assistere gli… Leggi tutto
Giu 06, 2025 322

Rettifica regolamento (UE) 2023/2055 - 06.06.2025

Rettifica regolamento (UE) 2023/2055 - 06.06.2025 ID 24080 | 06.06.2025 Rettifica del regolamento (UE) 2023/2055 della Commissione, del 25 settembre 2023, recante modifica dell’allegato XVII del regolamento (CE) n. 1907/2006 del Parlamento europeo e del Consiglio concernente la registrazione, la… Leggi tutto
Documento di orientamento CE condizioni d uso simili in tutta l Unione biocidi
Giu 04, 2025 331

Documento di orientamento CE condizioni d'uso simili in tutta l’Unione biocidi

Documento di orientamento CE condizioni d'uso simili in tutta l’Unione biocidi ID 24073 | 04.06.2025 / In allegato Comunicazione della Commissione - Documento di orientamento sulla definizione di condizioni d'uso simili in tutta l'Unione conformemente all'articolo 42, paragrafo 2, del regolamento… Leggi tutto
Decisione di esecuzione  UE  2025 1074
Giu 03, 2025 364

Decisione di esecuzione (UE) 2025/1074

Decisione di esecuzione (UE) 2025/1074 / Non approvazione ossido di etilene uso nei biocidi tipo di prodotto 2 ID 24066 | 03.06.2025 Decisione di esecuzione (UE) 2025/1074 della Commissione, del 2 giugno 2025, che non approva l’ossido di etilene come principio attivo esistente ai fini del suo uso… Leggi tutto
How to prepare a Drinking Water Directive Notification of intention
Mag 30, 2025 510

How to prepare a Drinking Water Directive Notification of intention

How to prepare a Drinking Water Directive Notification of intention / ECHA June 2025 ID 24047 | 30.05.2025 / Attached The purpose of this manual is to assist in the preparation of DWD notification of intention dossiers using IUCLID. The manual provides you with detailed and practical instructions… Leggi tutto
Mag 26, 2025 742

Regolamento di esecuzione (UE) 2025/973

Regolamento di esecuzione (UE) 2025/973 ID 24020 | 26.05.2025 Regolamento di esecuzione (UE) 2025/973 della Commissione, del 23 maggio 2025, recante modifica e rettifica del regolamento di esecuzione (UE) 2021/1165 che autorizza l’utilizzo di taluni prodotti e sostanze nella produzione biologica e… Leggi tutto

Più letti Chemicals

Notifica HACCP
Apr 05, 2022 101518

Notifica ai fini registrazione Regolamento CE n. 852/2004

Notifica ai fini della registrazione (Reg. CE n. 852/2004) - Ex notifica sanitaria alimentare ID 7901 | 06.03.2019 / Modello notifica allegato [panel]Regolamento (CE) 852/2004...Articolo 6 Controlli ufficiali, registrazione e riconoscimento 1. Gli operatori del settore alimentare collaborano con le… Leggi tutto